Handling of anger and ischemic stroke in women.
نویسنده
چکیده
Stroke welcomes Letters to the Editor and will publish them, if suitable, as space permits. They should not exceed 1,000 words (excluding references) and may be subject to editing or abridgment. Please submit Letters to the Editor in duplicate, typed double-spaced. Include an appropriate title and a fax number for the corresponding author. The American Heart Association requires that all authors sign a Copyright Transfer Agreement before publication. For a copy of this agreement, contact the Stroke Editorial Office. Adler reports that difficulties in the handling of anger occurred significantly more often in women with ischemic stroke. 1 This finding is supported by the stronger relationship of hostility traits with myocardial ischemia in women. 2 The neurobiology is suggested by studies linking disruption of brain stem cardiovascular control, cardiovascular reactivity in challenging tasks, vasospasm, and disordered mood and affect to dopamine abnormalities later-alized to the right hemisphere, in which the metabolic rate is higher in women. These findings prompt the assessment of dopa-minergic neurotransmission in interventions designed to modify response to personally relevant, emotionally arousing situations leading to ischemia. References 1. Adler RH. Do anger and aggression affect carotid atherosclerosis? A. Hostility and myocardial ischemia in coronary artery disease patients: evaluation by gender and ischemic index. We have read a letter to the editor and response that appeared recently in Stroke'-2 concerning apolipoprotein E genetic polymor-phism in patients with ischemic cerebrovascular disease (ICVD) and Alzheimer's disease. The allele frequencies given by Saunders and Roses 1 question our conclusion that the apo E4 allele probably could be a predisposing genetic marker for ICVD. 3 In this respect, we have calculated the allele frequencies by the gene counting method and compared the groups by the x 2 contingency test. Allele frequencies in control group were as follows: apo E2, 0.075; apo E3, 0.820; and apo E4, 0.105. These frequencies were significantly different from those in the ICVD patient group of 0.082, 0.720, and 0.198, respectively (P<.05), Therefore, we propose that a high apo E4 allele frequency in patients with ICVD, as has also been described in patients with coronary heart disease, 4 could be a genetic marker for atherosclerosis. References 1. Saunders AM, Roses AD. Apolipoprotein E4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease. Apolipoprotein E4 allele frequency , ischemic cerebrovascular disease, and Alzheimer's disease.haberriague L, Olive J. Lipoprotein and apolipoprotein profile in men with ischemic stroke: role of lipoprotein(a), triglyceride-rich …
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عنوان ژورنال:
- Stroke
دوره 25 2 شماره
صفحات -
تاریخ انتشار 1994